Ontology highlight
ABSTRACT:
SUBMITTER: Doyon WM
PROVIDER: S-EPMC3755901 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Doyon William M WM Dong Yu Y Ostroumov Alexey A Thomas Alyse M AM Zhang Tao A TA Dani John A JA
Neuron 20130718 3
Tobacco smoking is a well-known risk factor for subsequent alcohol abuse, but the neural events underlying this risk remain largely unknown. Alcohol and nicotine reinforcement involve common neural circuitry, including the mesolimbic dopamine system. We demonstrate in rodents that pre-exposure to nicotine increases alcohol self-administration and decreases alcohol-induced dopamine responses. The blunted dopamine response was due to increased inhibitory synaptic transmission onto dopamine neurons ...[more]