Ontology highlight
ABSTRACT:
SUBMITTER: Thayanithy V
PROVIDER: S-EPMC3755949 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Thayanithy Venugopal V Sarver Aaron L AL Kartha Reena V RV Li Lihua L Angstadt Andrea Y AY Breen Matthew M Steer Clifford J CJ Modiano Jaime F JF Subramanian Subbaya S
Bone 20111018 1
Osteosarcoma (OS) is the common histological form of primary bone cancer and one of the leading aggressive cancers in children under age fifteen. Although several genetic predisposing conditions have been associated with OS the understanding of its molecular etiology is limited. Here, we show that microRNAs (miRNAs) at the chr.14q32 locus are significantly downregulated in osteosarcoma compared to normal bone tissues. Bioinformatic predictions identified that a subset of 14q32 miRNAs (miR-382, m ...[more]