Ontology highlight
ABSTRACT:
SUBMITTER: Masui O
PROVIDER: S-EPMC3756906 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Masui Osamu O Bonnet Isabelle I Le Baccon Patricia P Brito Isabel I Pollex Tim T Murphy Niall N Hupé Philippe P Barillot Emmanuel E Belmont Andrew S AS Heard Edith E
Cell 20110401 3
Random X inactivation represents a paradigm for monoallelic gene regulation during early ES cell differentiation. In mice, the choice of X chromosome to inactivate in XX cells is ensured by monoallelic regulation of Xist RNA via its antisense transcription unit Tsix/Xite. Homologous pairing events have been proposed to underlie asymmetric Tsix expression, but direct evidence has been lacking owing to their dynamic and transient nature. Here we investigate the live-cell dynamics and outcome of Ts ...[more]