Role of plasma kallikrein in diabetes and metabolism.
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ABSTRACT:
SUBMITTER: Feener EP
PROVIDER: S-EPMC3757113 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
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Role of plasma kallikrein in diabetes and metabolism.
Feener E P EP Zhou Q Q Fickweiler W W
Thrombosis and haemostasis 20130516 3
Plasma kallikrein (PK) is a serine protease generated from plasma prekallikrein, an abundant circulating zymogen expressed by the Klkb1 gene. The physiological actions of PK have been primarily attributed to its production of bradykinin and activation of coagulation factor XII, which promotes inflammation and the intrinsic coagulation pathway. Recent genetic, molecular, and pharmacological studies of PK have provided further insight into its role in physiology and disease. Genetic analyses have ...[more]
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