Decreased plasma kallikrein activity is associated with reduced kidney function in individuals with type 1 diabetes.
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ABSTRACT:
SUBMITTER: Harma MA
PROVIDER: S-EPMC7286847 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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Decreased plasma kallikrein activity is associated with reduced kidney function in individuals with type 1 diabetes.
Härma Mari-Anne MA Dahlström Emma H EH Sandholm Niina N Forsblom Carol C Groop Per-Henrik PH Lehto Markku M
Diabetologia 20200408 7
<h4>Aims/hypothesis</h4>Plasma kallikrein is the central mediator of the plasma kallikrein-kinin system, which is involved both in vascular control and thrombin formation cascades. The plasma kallikrein-kinin system has also been considered protective in pathological conditions, but the impact of plasma kallikreins on diabetic nephropathy remains unknown. The objective of this cross-sectional study was to explore the association of plasma kallikrein with diabetic nephropathy.<h4>Methods</h4>We m ...[more]
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