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Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes.

ABSTRACT: Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.

SUBMITTER: Yin L 

PROVIDER: S-EPMC3757134 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes.

Yin Lichen L   Song Ziyuan Z   Kim Kyung Hoon KH   Zheng Nan N   Gabrielson Nathan P NP   Cheng Jianjun J  

Advanced materials (Deerfield Beach, Fla.) 20130218 22

Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude. ...[more]

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