Ontology highlight
ABSTRACT:
SUBMITTER: Jain PK
PROVIDER: S-EPMC7709491 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Jain Piyush K PK Lo Justin H JH Rananaware Santosh S Downing Marco M Panda Apekshya A Tai Michelle M Raghavan Srivatsan S Fleming Heather E HE Bhatia Sangeeta N SN
Nanoscale 20191031 44
There is a critical need for the development of safe and efficient delivery technologies for CRISPR/Cas9 to advance translation of genome editing to the clinic. Non-viral methods that are simple, efficient, and completely based on biologically-derived materials could offer such potential. Here we report a simple and modular tandem peptide-based nanocomplex system with cell-targeting capacity that efficiently combines guide RNA (sgRNA) with Cas9 protein, and facilitates internalization of sgRNA/C ...[more]