Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC3757224 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Yang Yang Y Liu Chang C Lin Yi-Lun YL Li Fang F
The Journal of biological chemistry 20130725 35
Hypertension is regulated through both the central and systemic renin-angiotensin systems. In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium. Here, we determined the crystal structures of human APA and its complexes with different ligands and identified a calcium-binding site in the S1 pocket of APA. Witho ...[more]