Ontology highlight
ABSTRACT:
SUBMITTER: Cheung J
PROVIDER: S-EPMC4321305 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cheung Jonah J Ginter Christopher C Cassidy Michael M Franklin Matthew C MC Rudolph Michael J MJ Robine Nicolas N Darnell Robert B RB Hendrickson Wayne A WA
Proceedings of the National Academy of Sciences of the United States of America 20150120 5
The extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of critical cell processes, including metabolism, gene expression, and cell proliferation; consequentially, mis-regulation of PKA signaling is implicated in tumorigenesis. Recent genomic studies have identified recurrent mutations in the catalytic subunit of PKA in tumors associated with Cushing's syndrome, a kidney disorder leading to excessive cortisol production, and also in tumors associated with fibr ...[more]