Ontology highlight
ABSTRACT:
SUBMITTER: Moslehi R
PROVIDER: S-EPMC3757356 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Moslehi Roxana R Mills James L JL Signore Caroline C Kumar Anil A Ambroggio Xavier X Dzutsev Amiran A
Scientific reports 20130101
We previously suggested links between specific XPD mutations in the fetal genome and the risk of placental maldevelopment and preeclampsia, possibly due to impairment of Transcription Factor (TF)IIH-mediated functions in placenta. To identify the underlying mechanisms, we conducted the current integrative analysis of several relevant transcriptome data sources. Our meta-analysis revealed downregulation of TFIIH subunits in preeclamptic placentas. Our overall integrative analysis suggested that, ...[more]