Ontology highlight
ABSTRACT:
SUBMITTER: Adams AC
PROVIDER: S-EPMC3757657 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Adams Andrew C AC Yang Chaofeng C Coskun Tamer T Cheng Christine C CC Gimeno Ruth E RE Luo Yongde Y Kharitonenkov Alexei A
Molecular metabolism 20120828 1
FGF21 is a multifunctional metabolic regulator. The co-factor βKlotho (KLB) allows FGF21 to signal via FGF receptors. Given the widespread nature of FGFR expression and KLB presence in several organs, it remains unclear which tissue/FGFR isoform determine FGF21 action. Here we show that deletion of FGFR1 in fat (FR1KO) leads to a complete ablation of FGF21 stimulated transcriptional activity in this tissue. Furthermore, FR1KO mice showed no FGF21-mediated lowering of plasma glucose, insulin and ...[more]