Ontology highlight
ABSTRACT:
SUBMITTER: Queen NJ
PROVIDER: S-EPMC7848733 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Queen Nicholas J NJ Bates Rhiannon R Huang Wei W Xiao Run R Appana Bhavya B Cao Lei L
Molecular therapy. Methods & clinical development 20201225
Fibroblast growth factor 21 (FGF21) is a peptide hormone that serves as a potent effector of energy homeostasis. Increasingly, FGF21 is viewed as a promising therapeutic agent for type 2 diabetes, fatty liver disease, and other metabolic complications. Exogenous administration of native FGF21 peptide has proved difficult due to unfavorable pharmacokinetic properties. Here, we utilized an engineered serotype adeno-associated viral (AAV) vector coupled with a dual-cassette design to selectively ov ...[more]