Ontology highlight
ABSTRACT:
SUBMITTER: Nagy LH
PROVIDER: S-EPMC3758347 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nagy Lauren H LH Grishina Irina I Macal Monica M Hirao Lauren A LA Hu William K WK Sankaran-Walters Sumathi S Gaulke Christopher A CA Pollard Richard R Brown Jennifer J Suni Maria M Baumler Andreas J AJ Ghanekar Smita S Marco Maria L ML Dandekar Satya S
PloS one 20130830 8
Chronic immune activation despite long-term therapy poses an obstacle to immune recovery in HIV infection. The role of antigen presenting cells (APCs) in chronic immune activation during HIV infection remains to be fully determined. APCs, the frontline of immune defense against pathogens, are capable of distinguishing between pathogens and non-pathogenic, commensal bacteria. We hypothesized that HIV infection induces dysfunction in APC immune recognition and response to some commensal bacteria a ...[more]