Ontology highlight
ABSTRACT:
SUBMITTER: Al-Barwani F
PROVIDER: S-EPMC4133192 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Al-Barwani Farah F Young Sarah L SL Baird Margaret A MA Larsen David S DS Ward Vernon K VK
PloS one 20140814 8
Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses. In this study we test the effect of surface mannosylation of protein-based virus-like particles (VLP) derived from Rabbit hemorrhagic disease virus (RHDV) on uptake by murine and human antigen presenting cells. A monomannoside and a novel dimannoside wer ...[more]