Ontology highlight
ABSTRACT:
SUBMITTER: Mathur BN
PROVIDER: S-EPMC3758434 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Mathur Brian N BN Tanahira Chiyoko C Tamamaki Nobuaki N Lovinger David M DM
Nature neuroscience 20130728 9
The dorsolateral striatum and cannabinoid type 1 receptor (CB1) signaling mediate habitual action learning, which is thought to require a balance of activity in the direct and indirect striatal output pathways. However, very little is known about how the high CB1-expressing striatal inhibitory microcircuitry might contribute to long-term plasticity capable of sculpting direct and indirect pathway output. Using optogenetic and molecular interrogation of striatal GABAergic microcircuits, we examin ...[more]