Fear-enhancing effects of septal oxytocin receptors.
Ontology highlight
ABSTRACT:
SUBMITTER: Guzman YF
PROVIDER: S-EPMC3758455 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Fear-enhancing effects of septal oxytocin receptors.
Guzmán Yomayra F YF Tronson Natalie C NC Jovasevic Vladimir V Sato Keisuke K Guedea Anita L AL Mizukami Hiroaki H Nishimori Katsuhiko K Radulovic Jelena J
Nature neuroscience 20130721 9
The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulat ...[more]
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