Targeting the RAS pathway in melanoma.
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ABSTRACT:
SUBMITTER: Ji Z
PROVIDER: S-EPMC3759017 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Targeting the RAS pathway in melanoma.
Ji Zhenyu Z Flaherty Keith T KT Tsao Hensin H
Trends in molecular medicine 20110930 1
Metastatic melanoma is a highly lethal type of skin cancer and is often refractory to all traditional chemotherapeutic agents. Key insights into the genetic makeup of melanoma tumors have led to the development of promising targeted agents. An activated RAS pathway, anchored by oncogenic BRAF, appears to be the central motor driving melanoma proliferation. Although recent clinical trials have brought enormous hope to patients with melanoma, adverse effects and novel escape mechanisms of these in ...[more]
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