Ontology highlight
ABSTRACT:
SUBMITTER: Daugaard M
PROVIDER: S-EPMC3759041 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
The Hace1-HECT E3 ligase is a tumor suppressor that ubiquitylates the activated GTP-bound form of the Rho family GTPase Rac1, leading to Rac1 proteasomal degradation. Here we show that, in vertebrates, Hace1 targets Rac1 for degradation when Rac1 is localized to the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase holoenzyme. This event blocks de novo reactive oxygen species generation by Rac1-dependent NADPH oxidases, and thereby confers cellular protection from reactive oxygen speci ...[more]