Ontology highlight
ABSTRACT:
SUBMITTER: Pal R
PROVIDER: S-EPMC3932663 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Pal Rituraj R Monroe Tanner O TO Palmieri Michela M Sardiello Marco M Rodney George G GG
FEBS letters 20131225 3
Neurodegenerative diseases are attributed to impairment of the ubiquitin-proteasome system (UPS). Oxidative stress has been considered a contributing factor in the pathology of impaired UPS by promoting protein misfolding and subsequent protein aggregate formation. Increasing evidence suggests that NADPH oxidase is a likely source of excessive oxidative stress in neurodegenerative disorders. However, the mechanism of activation and its role in impaired UPS is not understood. We show that activat ...[more]