Ontology highlight
ABSTRACT:
SUBMITTER: Yang Q
PROVIDER: S-EPMC3548425 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Yang Qi Q Saenz Steven A SA Zlotoff Daniel A DA Artis David D Bhandoola Avinash A
Journal of immunology (Baltimore, Md. : 1950) 20111024 11
Natural helper (NH) cells are recently discovered innate immune cells that confer protective type 2 immunity during helminth infection and mediate influenza-induced airway hypersensitivity. Little is known about the ontogeny of NH cells. We report in this study that NH cells derive from bone marrow lymphoid progenitors. Using RAG-1Cre/ROSA26(YFP) mice, we show that most NH cells are marked with a history of RAG-1 expression, implying lymphoid developmental origin. The development of NH cells dep ...[more]