Ontology highlight
ABSTRACT:
SUBMITTER: Liao JC
PROVIDER: S-EPMC3760383 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Liao Jack C C JC Lam Robert R Brazda Vaclav V Duan Shili S Ravichandran Mani M Ma Justin J Xiao Ting T Tempel Wolfram W Zuo Xiaobing X Wang Yun-Xing YX Chirgadze Nickolay Y NY Arrowsmith Cheryl H CH
Structure (London, England : 1993) 20110301 3
IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins. It has been implicated in transcriptional regulation by modulating protein-protein interactions with p53 tumor suppressor protein and other transcription factors. However, the mechanisms of interaction remain unknown. Here, we report the crystal structures of both HIN-A and HIN-B domains of IFI16 determined at 2.0 and 2.35 Å resolution, respectively. Each HIN domain comprises a pair of tightly packed OB-fold subdom ...[more]