Ontology highlight
ABSTRACT:
SUBMITTER: Worth DC
PROVIDER: S-EPMC3760615 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Worth Daniel C DC Daly Catherine N CN Geraldo Sara S Oozeer Fazal F Gordon-Weeks Phillip R PR
The Journal of cell biology 20130826 5
Drebrin is an actin filament (F-actin)-binding protein with crucial roles in neuritogenesis and synaptic plasticity. Drebrin couples dynamic microtubules to F-actin in growth cone filopodia via binding to the microtubule-binding +TIP protein EB3 and organizes F-actin in dendritic spines. Precisely how drebrin interacts with F-actin and how this is regulated is unknown. We used cellular and in vitro assays with a library of drebrin deletion constructs to map F-actin binding sites. We discovered t ...[more]