Silencing near tRNA genes requires nucleolar localization.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3761214 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Publications
Silencing near tRNA genes requires nucleolar localization.
Wang Li L Haeusler Rebecca A RA Good Paul D PD Thompson Martin M Nagar Sapna S Engelke David R DR
The Journal of biological chemistry 20050115 10
Transcription by RNA polymerase II is antagonized by the presence of a nearby tRNA gene in Saccharomyces cerevisiae. To test hypotheses concerning the mechanism of this tRNA gene-mediated (tgm) silencing, the effects of specific gene deletions were determined. The results show that the mechanism of silencing near tRNA genes is fundamentally different from other forms of transcriptional silencing in yeast. Rather, tgm silencing is dependent on the ability to cluster the dispersed tRNA genes in or ...[more]
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