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Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility.

ABSTRACT: Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that feature extension into the entrance channel near Glu138. Complexes of the parent anilinylpyrimidine 1 and the morpholinoethoxy analog 2j with HIV-RT have received crystallographic characterization confirming the designs. Measurement of aqueous solubilities of 2j, 2k, the parent triazene 2a, and other NNRTIs demonstrate profound benefits for addition of the morpholinyl substituent.

SUBMITTER: Bollini M

PROVIDER: S-EPMC3761378 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility.

Bollini Mariela M Frey Kathleen M KM Cisneros José A JA Spasov Krasimir A KA Das Kalyan K Bauman Joseph D JD Arnold Eddy E Anderson Karen S KS Jorgensen William L WL

Bioorganic & medicinal chemistry letters 20130708 18

Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that feature extension into the entrance channel near Glu138. Complexes of the parent anilinylpyrimidine 1 and the morpholinoethoxy analog 2j with HIV-RT have received crystallographic characterization confirming the designs. Measurement of aqueous solubilities of 2j, 2k, the parent triazene 2a, and other NNRTIs demonstrate profound benefits for addition of the morpholinyl substituent. ...[more]

PMID: 23899617

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