Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3761391 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Li Jing J Peng Jiangnan J Risinger April L AL Mooberry Susan L SL
Journal of natural products 20130715 7
The taccalonolides are microtubule stabilizers isolated from plants of the genus Tacca that show potent in vivo antitumor activity and the ability to overcome multiple mechanisms of drug resistance. The most potent taccalonolide identified to date, AJ, is a semisynthetic product generated from the major plant metabolite taccalonolide A in a two-step reaction. The first step involves hydrolysis of taccalonolide A to generate taccalonolide B, and then this product is oxidized to generate an epoxid ...[more]