Elevated hypermutation levels in HIV-1 natural viral suppressors.
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ABSTRACT:
SUBMITTER: Eyzaguirre LM
PROVIDER: S-EPMC3762252 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Elevated hypermutation levels in HIV-1 natural viral suppressors.
Eyzaguirre Lindsay M LM Charurat Manhattan M Redfield Robert R RR Blattner William A WA Carr Jean K JK Sajadi Mohammad M MM
Virology 20130619 2
Mutations in the HIV-1 proviral genomes delay the progression of the disease. We compared the mutation status in full-length proviral genomes of 23 HIV-infected patients with undetectable viral loads in the absence of therapy named natural viral suppressors (NVS) or Elite Controllers with 23 HIV-infected controls (10 patients on HAART treatment and 13 untreated patients). Provirus DNA was extracted from PBMC for amplification and sequencing to determine the mutation status. Nine (39 %) of the 23 ...[more]
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