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Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma.


ABSTRACT: PURPOSE:Genetic factors are shown to have a role in the development of primary open angle glaucoma (POAG). The aim of this study was to determine the effects of genetic polymorphisms of transient receptor potential melastatin (TRPM) channel genes on the risk of POAG in a Turkish population. METHODS:Genomic DNA was extracted from the leukocytes of the peripheral blood, and 26 single nucleotide polymorphisms in the TRPM channel genes were analyzed in 179 patients with POAG and in 182 healthy controls of similar age by using the BioMark HD dynamic array system. RESULTS:There were marked changes in the genotype (TT, 26.8%; CT, 66.7%; CC, 6.5%) and allele (T, 60.1%; C, 39.9%) frequencies for the TRPM5 gene rs34551253 (Ala456Thr, in exon 9) polymorphism in patients when compared to the controls (TT, 11.3%; CT, 74.6%; CC, 14.1%, p = 0.0009; T, 48.6%; A, 51.4%, p = 0.0063). However, no associations with the other 25 polymorphisms studied were found. CONCLUSIONS:This is the first study to examine the involvement of TRPM channel gene variations in the risk of incident POAG. This study demonstrated that the TRPM5 gene rs34551253 (Ala456Thr) polymorphism may be associated with increased risk of developing POAG in the Turkish population.

SUBMITTER: Okumus S 

PROVIDER: S-EPMC3762560 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma.

Okumus Seydi S   Demiryürek Seniz S   Gürler Bülent B   Coskun Erol E   Bozgeyik Ibrahim I   Oztuzcu Serdar S   Kaydu Erdal E   Celik Oguz O   Erbagcı Ibrahim I   Demiryürek Abdullah T AT  

Molecular vision 20130824


<h4>Purpose</h4>Genetic factors are shown to have a role in the development of primary open angle glaucoma (POAG). The aim of this study was to determine the effects of genetic polymorphisms of transient receptor potential melastatin (TRPM) channel genes on the risk of POAG in a Turkish population.<h4>Methods</h4>Genomic DNA was extracted from the leukocytes of the peripheral blood, and 26 single nucleotide polymorphisms in the TRPM channel genes were analyzed in 179 patients with POAG and in 18  ...[more]

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