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Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.

ABSTRACT: To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).The study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay.The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p?>?0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls. The minor 'C' allele frequency was 49.4%, which was comparable to the Japanese population and higher than the Indian and Afro-Caribbean populations. Similarly, no significant association was found between genotypes and systemic diseases and health awareness/behavior domain variables. Importantly, glaucoma specific indices, such as intraocular pressure, cup/disc ratio and number of anti-glaucoma medication, also showed no statistically significant effect of genotypes within POAG cases.Polymorphism rs540782 is not a risk factor for POAG in the Saudi cohort.

SUBMITTER: Kondkar AA 

PROVIDER: S-EPMC5290620 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.

Kondkar Altaf A AA   Edward Nikhil B NB   Kalantan Hatem H   Al-Kharashi Abdullah S AS   Altuwaijri Saleh S   Mohamed Gamal G   Sultan Tahira T   Azad Taif A TA   Abu-Amero Khaled K KK  

Journal of negative results in biomedicine 20170202 1

<h4>Background</h4>To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).<h4>Method</h4>The study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay.<h4>Results</h4>The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele freque  ...[more]

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