Ontology highlight
ABSTRACT:
SUBMITTER: Chang TK
PROVIDER: S-EPMC3762904 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Chang Tsun-Kai TK Shravage Bhupendra V BV Hayes Sebastian D SD Powers Christine M CM Simin Rachel T RT Wade Harper J J Baehrecke Eric H EH
Nature cell biology 20130721 9
Autophagy is a conserved process that delivers components of the cytoplasm to lysosomes for degradation. The E1 and E2 enzymes encoded by Atg7 and Atg3 are thought to be essential for autophagy involving the ubiquitin-like protein Atg8. Here, we describe an Atg7- and Atg3-independent autophagy pathway that facilitates programmed reduction of cell size during intestine cell death. Although multiple components of the core autophagy pathways, including Atg8, are required for autophagy and cells to ...[more]