Ontology highlight
ABSTRACT:
SUBMITTER: Frudd K
PROVIDER: S-EPMC5758830 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Frudd Karen K Burgoyne Thomas T Burgoyne Joseph Robert JR
Nature communications 20180108 1
Macroautophagy (autophagy) is a crucial cellular stress response for degrading defective macromolecules and organelles, as well as providing bioenergetic intermediates during hypoxia and nutrient deprivation. Here we report a thiol-dependent process that may account for impaired autophagy during aging. This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 and Atg7. When inactive Atg3 and Atg7 are protected from oxidation due to stable covalent interaction with their subst ...[more]