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Glycine receptor ?2 subunit activation promotes cortical interneuron migration.

ABSTRACT: Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the ?2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR ?2 activation that control cortical tangential migration during embryogenesis.

SUBMITTER: Avila A

PROVIDER: S-EPMC3763372 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Glycine receptor α2 subunit activation promotes cortical interneuron migration.

Avila Ariel A Vidal Pía M PM Dear T Neil TN Harvey Robert J RJ Rigo Jean-Michel JM Nguyen Laurent L

Cell reports 20130815 4

Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calci ...[more]

PMID: 23954789

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