Dataset Information

Cell-intrinsic regulation of interneuron migration controls cortical neurogenesis

ABSTRACT: Interneurons navigate along multiple tangential paths to settle into appropriate cortical layer. They undergo saltatory migration, which is paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. However, it remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes deglutamylation, is a pivotal regulator of pausing of cortical interneurons. Moreover, we show that pausing during migration controls the flow of interneurons invading the cortex by generating heterogeinity in movement at the population level. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also secondarily impairs the generation of age-matched upper layer projection neurons.

OTHER RELATED OMICS DATASETS IN: PRJNA408229

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Early Embryonic Cell

SUBMITTER: Sebastian Tanco

LAB HEAD: Petra Van Damme

PROVIDER: PXD006397 | Pride | 2018-02-14

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	E08415_1p_4630_Sebastian_CCP1KO_11.raw	Raw
	E08416_2p_4630_Sebastian_CCP1KO_12.raw	Raw
	E08417_1p_4630_Sebastian_CCP1KO_13.raw	Raw
	E08418_2p_4630_Sebastian_CCP1KO_14.raw	Raw
	E08419_1p_4630_Sebastian_CCP1KO_15.raw	Raw

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Publications

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.

Silva Carla G CG Peyre Elise E Adhikari Mohit H MH Tielens Sylvia S Tanco Sebastian S Van Damme Petra P Magno Lorenza L Krusy Nathalie N Agirman Gulistan G Magiera Maria M MM Kessaris Nicoletta N Malgrange Brigitte B Andrieux Annie A Janke Carsten C Nguyen Laurent L

Cell 20180201 5

Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, whic ...[more]

PMID: 29474907

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