Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang R
PROVIDER: S-EPMC3763549 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Zhuang Ran R Rao Jaladanki N JN Zou Tongtong T Liu Lan L Xiao Lan L Cao Shan S Hansraj Natasha Z NZ Gorospe Myriam M Wang Jian-Ying JY
Nucleic acids research 20130626 16
Stromal interaction molecule 1 (Stim1) functions as a sensor of Ca2+ within stores and plays an essential role in the activation of store-operated Ca2+ entry (SOCE). Although lowering Stim1 levels reduces store-operated Ca2+ entry and inhibits intestinal epithelial repair after wounding, the mechanisms that control Stim1 expression remain unknown. Here, we show that cellular Stim1 abundance is controlled posttranscriptionally via factors that associate with 3'-untranslated region (3'-UTR) of sti ...[more]