Ontology highlight
ABSTRACT:
SUBMITTER: Dormoy-Raclet V
PROVIDER: S-EPMC4005793 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Upon muscle injury, the high mobility group box 1 (HMGB1) protein is upregulated and secreted to initiate reparative responses. Here we show that HMGB1 controls myogenesis both in vitro and in vivo during development and after adult muscle injury. HMGB1 expression in muscle cells is regulated at the translational level: the miRNA miR-1192 inhibits HMGB1 translation and the RNA-binding protein HuR promotes it. HuR binds to a cis-element, HuR binding sites (HuRBS), located in the 3'UTR of the HMGB ...[more]