Identification of active regulatory regions from DNA methylation data.

ABSTRACT: We have recently shown that transcription factor binding leads to defined reduction in DNA methylation, allowing for the identification of active regulatory regions from high-resolution methylomes. Here, we present MethylSeekR, a computational tool to accurately identify such footprints from bisulfite-sequencing data. Applying our method to a large number of published human methylomes, we demonstrate its broad applicability and generalize our previous findings from a neuronal differentiation system to many cell types and tissues. MethylSeekR is available as an R package at www.bioconductor.org.

SUBMITTER: Burger L 

PROVIDER: S-EPMC3763559 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature