Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription factor occupancy is linked to DNA methylation turnover at active regulatory regions

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE39739 | GEO | 2013/12/24

SECONDARY ACCESSION(S): PRJNA171566

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions.

Project description: Not available

| S-EPMC3868540 | biostudies-literature

Transcription factor occupancy is linked to DNA methylation turnover at active regulatory regions [Bisulfite-Seq]

Project description:Genome wide analysis revealed that distal regulatory elements form Low Methylated Regions (LMRs). Even though transcription factor binding is required for LMR formation, we show for the test case CTCF that actual occupancy does not distinguish DNA methylation states. However, in line with a dynamic model of binding and DNA methylation turnover, we find that the product of active demethylation, 5-hydroxymethylcytosine (5hmC), is enriched at LMRs. 5hmC is present at active regulatory regions in stem and somatic cells and as a result a substantial fraction of changes in 5hmC occurs at LMRs. This suggests that transcription factor binding mediates active turnover of DNA methylation as an integral part of reprogramming of regulatory regions.

2013-12-24 | GSE39736 | GEO

Transcription factor occupancy is linked to DNA methylation turnover at active regulatory regions [MeDIP-Seq]

2013-12-24 | GSE39738 | GEO