Ontology highlight
ABSTRACT:
SUBMITTER: Irimia D
PROVIDER: S-EPMC3763904 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Irimia Daniel D Liu Su-Yang SY Tharp William G WG Samadani Azadeh A Toner Mehmet M Poznansky Mark C MC
Lab on a chip 20051223 2
Experimental systems that provide temporal and spatial control of chemical gradients are required for probing into the complex mechanisms of eukaryotic cell chemotaxis. However, no current technique can simultaneously generate stable chemical gradients and allow fast gradient changes. We developed a microfluidic system with microstructured membranes for exposing neutrophils to fast and precise changes between stable, linear gradients of the known chemoattractant Interleukin-8 (IL-8). We observed ...[more]