Dataset Information

Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort.

ABSTRACT:

Background

Air pollution and obesity are hypothesized to contribute to accelerated decline in lung function with age through their inflammatory properties.

Objective

We investigated whether the previously reported association between improved air quality and lung health in the population-based SAPALDIA cohort is modified by obesity.

Methods

We used adjusted mixed-model analyses to estimate the association of average body mass index (BMI) and changes in particulate matter with aerodynamic diameter ? 10 µm (PM10; ?PM10) with lung function decline over a 10-year follow-up period.

Results

Lung function data and complete information were available for 4,664 participants. Age-related declines in lung function among participants with high average BMI were more rapid for FVC (forced vital capacity), but slower for FEV1/FVC (forced expiratory volume in 1 sec/FVC) and FEF25-75 (forced expiratory flow at 25-75%) than declines among those with low or normal average BMI. Improved air quality was associated with attenuated reductions in FEV1/FVC, FEF25-75, and FEF25-75/FVC over time among low- and normal-BMI participants, but not overweight or obese participants. The attenuation was most pronounced for ?FEF25-75/FVC (30% and 22% attenuation in association with a 10-?g/m3 decrease in PM10 among low- and normal-weight participants, respectively.)

Conclusion

Our results point to the importance of considering health effects of air pollution exposure and obesity in parallel. Further research must address the mechanisms underlying the observed interaction.

SUBMITTER: Schikowski T

PROVIDER: S-EPMC3764076 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Publications

Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort.

Schikowski Tamara T Schaffner Emmanuel E Meier Flurina F Phuleria Harish C HC Vierkötter Andrea A Schindler Christian C Kriemler Susi S Zemp Elisabeth E Krämer Ursula U Bridevaux Pierre-Olivier PO Rochat Thierry T Schwartz Joel J Künzli Nino N Probst-Hensch Nicole N

Environmental health perspectives 20130702 9

<h4>Background</h4>Air pollution and obesity are hypothesized to contribute to accelerated decline in lung function with age through their inflammatory properties.<h4>Objective</h4>We investigated whether the previously reported association between improved air quality and lung health in the population-based SAPALDIA cohort is modified by obesity.<h4>Methods</h4>We used adjusted mixed-model analyses to estimate the association of average body mass index (BMI) and changes in particulate matter wi ...[more]

PMID: 23820868

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Dataset Information

Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort.

Background

Objective

Methods

Results

Conclusion

Publications

Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort.

Similar Datasets

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