Ontology highlight
ABSTRACT:
SUBMITTER: Viskov C
PROVIDER: S-EPMC3764794 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20130710 36
The antithrombin (AT) binding properties of heparin and low molecular weight heparins are strongly associated to the presence of the pentasaccharide sequence AGA*IA (A(NAc,6S)-GlcUA-A(NS,3,6S)-I(2S)-A(NS,6S)). By using the highly chemoselective depolymerization to prepare new ultra low molecular weight heparin and coupling it with the original separation techniques, it was possible to isolate a polysaccharide with a biosynthetically unexpected structure and excellent antithrombotic properties. I ...[more]