Ontology highlight
ABSTRACT:
SUBMITTER: Viskov C
PROVIDER: S-EPMC3764794 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Viskov Christian C Elli Stefano S Urso Elena E Gaudesi Davide D Mourier Pierre P Herman Frederic F Boudier Christian C Casu Benito B Torri Giangiacomo G Guerrini Marco M
The Journal of biological chemistry 20130710 36
The antithrombin (AT) binding properties of heparin and low molecular weight heparins are strongly associated to the presence of the pentasaccharide sequence AGA*IA (A(NAc,6S)-GlcUA-A(NS,3,6S)-I(2S)-A(NS,6S)). By using the highly chemoselective depolymerization to prepare new ultra low molecular weight heparin and coupling it with the original separation techniques, it was possible to isolate a polysaccharide with a biosynthetically unexpected structure and excellent antithrombotic properties. I ...[more]