Unknown

Dataset Information

0

The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis.


ABSTRACT: There is increasing evidence that infection with the Epstein-Barr virus (EBV) plays a role in the development of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the CNS. This article provides a four-tier hypothesis proposing (1) EBV infection is essential for the development of MS; (2) EBV causes MS in genetically susceptible individuals by infecting autoreactive B cells, which seed the CNS where they produce pathogenic autoantibodies and provide costimulatory survival signals to autoreactive T cells that would otherwise die in the CNS by apoptosis; (3) the susceptibility to develop MS after EBV infection is dependent on a genetically determined quantitative deficiency of the cytotoxic CD8+ T cells that normally keep EBV infection under tight control; and (4) sunlight and vitamin D protect against MS by increasing the number of CD8+ T cells available to control EBV infection. The hypothesis makes predictions that can be tested, including the prevention and successful treatment of MS by controlling EBV infection.

SUBMITTER: Pender MP 

PROVIDER: S-EPMC3764840 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis.

Pender Michael P MP  

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 20101112 4


There is increasing evidence that infection with the Epstein-Barr virus (EBV) plays a role in the development of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the CNS. This article provides a four-tier hypothesis proposing (1) EBV infection is essential for the development of MS; (2) EBV causes MS in genetically susceptible individuals by infecting autoreactive B cells, which seed the CNS where they produce pathogenic autoantibodies and provide costimulatory survival s  ...[more]

Similar Datasets

| S-EPMC9362539 | biostudies-literature
| S-EPMC3355105 | biostudies-other
| S-EPMC6456696 | biostudies-literature
| S-EPMC6957475 | biostudies-literature
| S-EPMC7335184 | biostudies-literature
| S-EPMC4388746 | biostudies-literature
| S-EPMC7106557 | biostudies-literature
| S-EPMC2118531 | biostudies-literature
| S-EPMC3806908 | biostudies-literature
| S-EPMC5649756 | biostudies-literature