Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer's disease in Han Chinese.

ABSTRACT: BACKGROUND: Toll-like receptors (TLRs), as major innate immune mediators, may be involved in clearance of cerebral amyloid-? (A?) deposits. Recently, a novel TLR9 signaling pathway has been uncovered, which is functionally associated with the immune inflammatory response and reducing A? burden in Alzheimer's disease (AD) mice. Therefore, TLR9 might represent a reasonable functional candidate gene for AD. FINDINGS: Our study investigated 1,133 sporadic late-onset AD (LOAD) and 1,159 healthy controls matched for sex and age in a large Han Chinese population. One selected functional rs187084 polymorphism within the TLR9 gene was genotyped by polymerase chain reaction-ligase detection reaction in a case-control associated study. The TLR9 rs187084 variant homozygote GG was significantly associated with a decreased LOAD risk after adjusting for age, gender, and ApoE ?4 status by logistic regression analysis (P?=?0.035). Our result showed significant evidence of the interaction of ApoE ?4 with rs187084. When we further stratified our data by the ApoE ?4 status, we detected significant differences in the genotype and allele distributions of rs187084 between LOAD patients and controls in ApoE ?4 carriers (P?

SUBMITTER: Wang YL 

PROVIDER: S-EPMC3765501 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature