Dataset Information

Racial/ethnic differences in clinical and biochemical type 2 diabetes mellitus risk factors in children.

ABSTRACT:

Objective

To examine whether periadolescent children demonstrate the significant racial/ethnic differences in body fatness relative to BMI and in the prevalence and relationship of body composition to risk factors for type 2 diabetes (T2DM) as in adults.

Design and methods

Family history of obesity and T2DM, anthropometry, insulin sensitivity and secretory capacity, lipids, and cytokines (IL-6, CRP, TNF-α, and adiponectin) were examined in a cohort of 994 middle school students (47% male, 53%, female; 12% African American, 14% East Asian, 13% South Asian, 9% Caucasian, 44% Hispanic, and 8% other).

Results

Fractional body fat content was significantly greater at any BMI among South Asians. There were racial/ethnic specific differences in lipid profiles, insulin secretory capacity, insulin sensitivity, and inflammatory markers corrected for body fatness that are similar to those seen in adults. Family history of T2DM was associated with lower insulin secretory capacity while family history of obesity was more associated with insulin resistance.

Conclusions

Children show some of the same racial/ethnic differences in risk factors for adiposity-related comorbidities as adults. BMI and waist circumference cutoffs to identify children at-risk for adiposity-related comorbidities should be adjusted by racial/ethnic group as well as other variables such as birthweight and family history.

SUBMITTER: Rosenbaum M

PROVIDER: S-EPMC3766484 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Publications

Racial/ethnic differences in clinical and biochemical type 2 diabetes mellitus risk factors in children.

Rosenbaum Michael M Fennoy Ilene I Accacha Siham S Altshuler Lisa L Carey Dennis E DE Holleran Stephen S Rapaport Robert R Shelov Steven P SP Speiser Phyllis W PW Ten S S Bhangoo Amrit A Boucher-Berry Claudia C Espinal Yomery Y Gupta Rishi R Hassoun Abeer A AA Iazetti Loretta L Jean-Jacques Fabienne F Jean Amy M AM Klein Michelle L ML Levine Robet R Lowell Barbara B Michel Lesley L Rosenfeld Warren W

Obesity (Silver Spring, Md.) 20130705 10

<h4>Objective</h4>To examine whether periadolescent children demonstrate the significant racial/ethnic differences in body fatness relative to BMI and in the prevalence and relationship of body composition to risk factors for type 2 diabetes (T2DM) as in adults.<h4>Design and methods</h4>Family history of obesity and T2DM, anthropometry, insulin sensitivity and secretory capacity, lipids, and cytokines (IL-6, CRP, TNF-α, and adiponectin) were examined in a cohort of 994 middle school students (4 ...[more]

PMID: 23596082

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Project description:ObjectiveRacial and ethnic disparities in rheumatoid arthritis (RA) disease activity measures have been documented. We compared racial and ethnic differences in disease activity using multiple composite measures, including an objective measure, the multi-biochemical disease activity (MBDA) score.MethodsData are derived from the University of California, San Francisco RA Cohort, a longitudinal observational cohort. Participants with at least one MBDA measure and self-reported race and ethnicity were included. Multivariable linear regression evaluated the association between race and ethnicity groups and mean MBDA score, adjusting for potential confounders, including symptom duration and medication use. Sensitivity analyses substituted the Clinical Disease Activity Index (CDAI) and the Disease Activity Score-28 joints with erythrocyte sedimentation rate (DAS28-ESR) for the MBDA in multivariable models.ResultsWe included 267 participants (86% female, mean age 52.7 ± 13.3 years). The majority were Latinx (n = 137; 51%), followed by Asian (n = 91; 34%). After adjustment, Latinx participants had the highest mean MBDA score (40.6 ± 2.1) compared with White participants at (32.8 ± 6.7). Black participants had the second highest mean MBDA score, followed by Asian participants (36.3 ± 5.3, 36.0 ± 2.7, respectively), although neither were significantly different from White participants. The trends observed for the CDAI and DAS28-ESR were similar to those for the MBDA.ConclusionWe found significantly higher disease activity measured by the MBDA and DAS28-ESR in Latinx participants compared with White participants. We also found significantly higher disease activity in Asian participants compared with White participants with the DAS28-ESR. Our findings, although limited by the small number of White participants in the referent group, suggest that RA disease activity measures may be influenced by external factors that have differential impacts by racial and ethnic group.

Dataset Information

Racial/ethnic differences in clinical and biochemical type 2 diabetes mellitus risk factors in children.

Objective

Design and methods

Results

Conclusions

Publications

Racial/ethnic differences in clinical and biochemical type 2 diabetes mellitus risk factors in children.

Similar Datasets

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