Ontology highlight
ABSTRACT:
SUBMITTER: Dwivedi Y
PROVIDER: S-EPMC3767381 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20130319 5
Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an important role in the maintenance and survival of neurons, synaptic integrity, and synaptic plasticity. Evidence suggests that BDNF is involved in major depression, such that the level of BDNF is decreased in depressed patients and that antidepressants reverse this decrease. Stress, a major factor in depression, also modulates BDNF expression. These studies have led to the proposal of the neurotrophin hypot ...[more]