Ontology highlight
ABSTRACT:
SUBMITTER: Ji Y
PROVIDER: S-EPMC3767463 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Ji Yanbin Y Majumder Subhabrata S Millard Melissa M Borra Radhika R Bi Tao T Elnagar Ahmed Y AY Neamati Nouri N Shekhtman Alexander A Camarero Julio A JA
Journal of the American Chemical Society 20130725 31
The overexpression of Hdm2 and HdmX is a common mechanism used by many tumor cells to inactive the p53 tumor suppressor pathway promoting cell survival. Targeting Hdm2 and HdmX has emerged as a validated therapeutic strategy for treating cancers with wild-type p53. Small linear peptides mimicking the N-terminal fragment of p53 have been shown to be potent Hdm2/HdmX antagonists. The potential therapeutic use of these peptides, however, is limited by their poor stability and bioavailability. Here, ...[more]