Ontology highlight
ABSTRACT:
SUBMITTER: Xu K
PROVIDER: S-EPMC3767517 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Xu Kai K Tzvetkova-Robev Dorothea D Xu Yan Y Goldgur Yehuda Y Chan Yee-Peng YP Himanen Juha P JP Nikolov Dimitar B DB
Proceedings of the National Academy of Sciences of the United States of America 20130819 36
Eph receptor tyrosine kinases and their ephrin ligands mediate cell signaling during normal and oncogenic development. Eph signaling is initiated in a multistep process leading to the assembly of higher-order Eph/ephrin clusters that set off bidirectional signaling in interacting cells. Eph and ephrins are divided in two subclasses based on their abilities to bind and activate each other and on sequence conservation. EphA4 is an exception to the general rule because it can be activated by both A ...[more]