Ontology highlight
ABSTRACT:
SUBMITTER: Lavelin I
PROVIDER: S-EPMC3767655 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lavelin Irena I Wolfenson Haguy H Patla Israel I Henis Yoav I YI Medalia Ohad O Volberg Tova T Livne Ariel A Kam Zvi Z Geiger Benjamin B
PloS one 20130909 9
Treatment of cultured cells with inhibitors of actomyosin contractility induces rapid deterioration of stress fibers, and disassembly of the associated focal adhesions (FAs). In this study, we show that treatment with the Rho kinase inhibitor Y-27632, which blocks actomyosin contractility, induces disarray in the FA-associated actin bundles, followed by the differential dissociation of eight FA components from the adhesion sites. Live-cell microscopy indicated that the drug triggers rapid dissoc ...[more]