Proteomics

Dataset Information

0

Effect of TPA on focal adhesion composition


ABSTRACT: Effect of a tumor promoter TPA on collagen IV based focal adhesions from CHO cells expressing human integrin alpha1 with activating mutation E317A

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Cricetulus Griseus (chinese Hamster) (cricetulus Barabensis Griseus)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Pekka Rappu  

LAB HEAD: Jyrki Heino

PROVIDER: PXD003153 | Pride | 2016-07-11

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
130306Pekka_Export_peptide_norm2all.csv Csv
130306Pekka_Export_protein_norm2all.csv Csv
130306_PekkaR_EtOH1.raw Raw
130306_PekkaR_EtOH2.raw Raw
130306_PekkaR_EtOH3.raw Raw
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Publications

Tumor promoter PMA enhances kindlin-2 and decreases vimentin recruitment into cell adhesion sites.

Salmela Maria M   Rappu Pekka P   Lilja Johanna J   Niskanen Henri H   Taipalus Elina E   Jokinen Johanna J   Heino Jyrki J  

The international journal of biochemistry & cell biology 20160629


Phorbol diester PMA (phorbol 12-myristate 13-acetate) is a well-known promoter of tumor progression. PMA also regulates cell adhesion by several mechanisms including conformational activation of integrins and integrin clustering. Here, PMA was shown to induce lamellipodia formation and reorganization of the adhesion sites as well as actin and vimentin filaments independently of integrin preactivation. To further analyze the mechanism of PMA action, the protein composition in the α1β1 integrin/co  ...[more]

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