Ontology highlight
ABSTRACT:
SUBMITTER: Shekhar N
PROVIDER: S-EPMC3768200 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Shekhar Nandini N Neelam Srujana S Wu Jun J Ladd Anthony Jc AJ Dickinson Richard B RB Lele Tanmay P TP
Cellular and molecular bioengineering 20130601 2
Despite their rigidity, microtubules in living cells bend significantly during polymerization resulting in greater curvature than can be explained by thermal forces alone. However, the source of the non-thermal forces that bend growing microtubules remains obscure. We analyzed the motion of microtubule tips in NIH-3T3 fibroblasts expressing EGFP-EB1, a fluorescent +TIP protein that specifically binds to the growing ends of microtubules. We found that dynein inhibition significantly reduced the d ...[more]