Ontology highlight
ABSTRACT:
SUBMITTER: Zhou D
PROVIDER: S-EPMC3769925 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
American journal of human genetics 20130815 3
The hypoxic conditions at high altitudes present a challenge for survival, causing pressure for adaptation. Interestingly, many high-altitude denizens (particularly in the Andes) are maladapted, with a condition known as chronic mountain sickness (CMS) or Monge disease. To decode the genetic basis of this disease, we sequenced and compared the whole genomes of 20 Andean subjects (10 with CMS and 10 without). We discovered 11 regions genome-wide with significant differences in haplotype frequenci ...[more]