Ontology highlight
ABSTRACT:
SUBMITTER: Cole AM
PROVIDER: S-EPMC4273201 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
High altitude medicine & biology 20141201 4
Chronic mountain sickness (CMS) is a serious illness that affects life-long high-altitude residents. A recent study analyzed whole genome sequence data from residents of Cerro de Pasco (Peru) in an effort to identify the genetic basis of CMS and reported SENP1 (rs7963934) and ANP32D (rs72644851) to show signatures consistent with natural selection and protective against CMS (Zhou et al. 2013 ). We set out to replicate these observations in two Andean cohorts from Cerro de Pasco, consisting of 84 ...[more]